SETBP1 single gene test
Methodology
Molecular
Test Description and clinical significance
Genes
SETBP1
Disease:
Juvenile myelomonocytic leukemia, acute myeloid leukemia, chronic myeloid leukemia, myelodysplastic neoplasm, lung adenocarcinoma, colon adenocarcinoma, melanoma, endometrial endometrioid adenocarcinoma, and Schinzel-Giedion midface retraction syndrome
Next generation sequencing of gene panel. This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication.
Specimen Requirements
Collection:
At least 0.5 ml EDTA, citrate (ACD) or Heparinized whole blood or bone marrow aspirates for DNA mutations
Stability:
96hours/4 to 7 days refrigerated
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative or anticoagulant. Specimen received after the stability date. Gross hemolysis. Frozen specimen. Insufficient specimen. Unlabeled. Left un-refrigerated for an extended period.
Storage & Transport
Blood, bone marrow specimens should be kept at room temperature and preferably received within 96 hrs of drawing. Samples that are 4 to 7 days old should be refrigerated.
CPT(s)
81479
New York Approved
NO
TAT
10 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
