PIK3CA LDT Heme Mutation Analysis
Alternative name:
PI3K Mutation Analysis
Methodology
Molecular
Test Description and clinical significance
Genes
PIK3CA (exons 9-11, 20-21)
Disease:
Colon cancer, glioma, gastric cancer, breast cancer, endometrial cancer, lung cancer, Megalencephaly-Capillary Malformation-Polymicrogyria Syndrome, Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi
Deep next generation sequencing of gene panel. PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) is a gene that encodes the protein phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, a subunit of the PI3K protein. Phosphatidyl 3-kinases (PI3K) are a family of lipid kinases involved in many cellular processes, including cell growth, proliferation, differentiation, motility, and survival. Mutant PIK3CA has been implicated in the pathogenesis of several cancers.
Specimen Requirements
Collection:
Specimen should contain atleast 0.5 mL of EDTA, citrate (ACD) or Heparinized bone marrow and peripheral blood specimens
Stability:
96hours/4 to 7 days refrigerated
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative or anticoagulant.Specimen received after the stability date. Gross hemolysis. Frozen specimen. Insufficient specimen. Unlabeled. Left un-refrigerated for an extended period.
Storage & Transport
Blood specimens should be kept at room temperature and preferably received within 96 hours of drawing. Samples that are 4 to 7 days old should be refrigerated
CPT(s)
81309
New York Approved
NO
TAT
7 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
