NRAS Heme Mutation Analysis
Methodology
Molecular
Test Description and clinical significance
Genes
NRAS
Disease:
Giant congenital melanocytic nevus, Noonan syndrome, Autoimmune lymphoproliferative syndrome, Cholangiocarcinoma, Core binding factor acute myeloid leukemia, Cytogenetically normal acute myeloid leukemia, Epidermal nevus,Lung cancer,Melanoma, and colon cancer
Next generation sequencing of gene panel. NRAS (neuroblastoma RAS viral (v-ras) oncogene homolog) encodes for the GTPase NRas protein, one of three human RAS proteins. RAS proteins are small GTPases that are central mediators downstream of growth factor receptor signaling and therefore critical for cell proliferation, survival, and differentiation
Specimen Requirements
Collection:
At least 0.5 ml EDTA, citrate (ACD) or Heparinized whole blood or bone marrow aspirates for DNA mutations
Stability:
96hours/4 to 7 days refrigerated
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative or anticoagulant. Specimen received after the stability date. Gross hemolysis. Frozen specimen. Insufficient specimen. Unlabeled. Left un-refrigerated for an extended period.
Storage & Transport
Blood, bone marrow specimens should be kept at room temperature and preferably received within 96 hrs of drawing. Samples that are 4 to 7 days old should be refrigerated.
CPT(s)
81311
New York Approved
NO
TAT
10 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
