NOTCH1 Mutation Analysis
Alternative name:
NOTCH1 Gene Sequencing
Methodology
Molecular
Test Description and clinical significance
Genes
NOTCH1 (exons 25-28, 34)
Disease:
Esophageal cancer, hematopoietic and lymphoid cancers, stomach cancer, colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, endometrial endometrioid adenocarcinoma, and skin squamous cell carcinoma, aortic valve disease, and Adams-Oliver syndrome
Deep next generation sequencing of gene panel.Notch 1 (NOTCH1) is a gene that encodes a transmembrane protein that functions in multiple developmental processes and the interactions between adjacent cells. The transmembrane protein also functions as a receptor for membrane bound ligands
Specimen Requirements
Collection:
Specimen should contain atleast 0.5 mL of EDTA, citrate (ACD) or Heparinized bone marrow and peripheral blood specimens
Stability:
96hours/4 to 7 days refrigerated
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative or anticoagulant.Specimen received after the stability date. Gross hemolysis. Frozen specimen. Insufficient specimen. Unlabeled. Left un-refrigerated for an extended period.
Storage & Transport
Blood specimens should be kept at room temperature and preferably received within 96 hours of drawing. Samples that are 4 to 7 days old should be refrigerated
CPT(s)
81407
New York Approved
NO
TAT
7 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
