MYD88 Mutation Analysis
Alternative name:
Myeloid Differentiation Primary Response 88
Methodology
Molecular
Test Description and clinical significance
Genes
MYD88 (exons 3-5) including detection of the common L265P variant
Disease:
Waldenstrom macroglobulinemia (WM), IgM-MGUS, diffuse large B-cell lymphoma (DLBCL) and marginal zone lymphoma (MZL)
Next generation sequencing of gene panel. This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes.
Specimen Requirements
Collection:
At least 0.5 ml EDTA, citrate (ACD) or Heparinized whole blood or bone marrow aspirates for DNA mutations
Stability:
96hours/4 to 7 days refrigerated
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative or anticoagulant. Specimen received after the stability date. Gross hemolysis. Frozen specimen. Insufficient specimen. Unlabeled. Left un-refrigerated for an extended period.
Storage & Transport
Blood, bone marrow specimens should be kept at room temperature and preferably received within 96 hrs of drawing. Samples that are 4 to 7 days old should be refrigerated.
CPT(s)
81305
New York Approved
NO
TAT
7-10 days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
