IGH (B-Cell Gene rearrangement)
Methodology
Molecular
Test Description and clinical significance
Genes
IGH
Disease:
Diffuse large B-cell lymphoma, follicular lymphoma, mature B-cell neoplasm, chronic lymphocytic leukemia/small lymphocytic lymphoma, and breast invasive ductal carcinoma.
Gene rearrangement studies prove clonality for B cell lymphomas and rarely T cell lymphomas.
Specimen Requirements
Collection:
2 ml of peripheral blood or bone marrow aspirate anti-coagulated with heparin or EDTA, Fresh tissue (5mm) in RPMI or saline, Formalin-fixed paraffin embedded tissue or slides, Body fluids (CSF, pleural or ascetic fluid) in RPMI or without fixative
Stability:
96hours/4 to 7 days refrigerated
Unacceptable Conditions:
Unlabeled or improperly labeled samples, Samples older than stability date, Gross hemolysis, Decalcified specimens or specimens fixed in B5
Storage & Transport
Blood or bone marrow specimens should be kept at room temperature and preferably arrives in the lab within 96 hrs of drawing. Samples that are 4 to 7 days old should be refrigerated. Fresh tissue should be shipped on ice. Body fluids should be shipped within 48 hrs of collection.
CPT(s)
81261 if amplified methodology (eg, polymerase chain reaction) & 81262 if direct probe methodology (eg, Southern blot) & 81263 if variable region somatic mutation analysis
New York Approved
NO
TAT
5 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
