Lynch Syndrome & Hereditary Colon Cancer Risk Assessment Panel (Germline)
Alternative name:
NGS–Lynch/Colon Cancer HCP (Hereditary Cancer Panel)
Methodology
Molecular
Test Description and clinical significance
Genes
APC, CHEK2, MSH3, PMS2, SMAD4, AXIN2, EPCAM, MSH6, POLD1, STK11, BMPR1A, MLH1, MUTYH, POLE, TP53, CDH1, MSH2, NTHL1, PTEN
Disease:
Colon cancer, Lynch syndrome
This test is used to identify individuals with a hereditary predisposition to colon cancer. Two different technologies (NGS and Microarray) are combined for a comprehensive diagnostic panel. Two different technologies (NGS and Microarray) are combined for a comprehensive diagnostic panel. It is most useful for individuals with a personal or family history of colon cancer that does not clearly point to a specific cancer syndrome. This multigene panel can also identify individuals with a hereditary cancer predisposition when the clinical suspicion remains high despite a negative result on a single-gene/syndrome genetic test. This test is also used to identify individuals with Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC) syndrome.
Specimen Requirements
Collection:
Specimen should contain least 0.5 mL of blood, Previously extracted DNA is acceptable if stored at appropriate temperature (short term at 2–8 C or long term at -20 C) and should be transported on ice. A minimum of 20 µl of DNA with a concentration of at least 5ng/µl by Qubit using Qubit HS dsDNA assay and an OD260/280 ratio of 1.7-1.9 obtained on a spectrophotometer is required
Stability:
96hours/4 to 7 days refrigerated
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative or anticoagulant. Specimen received after the stability date. Gross hemolysis. Frozen specimen. Insufficient specimen. Unlabeled. Left un-refrigerated for an extended period.
Storage & Transport
Blood specimens should be kept at room temperature and preferably received within 96 hours of drawing. Samples that are 4 to 7 days old should be refrigerated
CPT(s)
81435
New York Approved
YES
TAT
21 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
