MLL Single Gene
Methodology
Molecular
Test Description and clinical significance
Genes
(MLL)
Disease:
Acute Myeloid Leukemia & Acute Lymphoblastic Leukemia
Next generation sequencing of gene panel. The MLL complex plays a crucial role during embryonic development, is active in stem cells (bivalent marks) and maintains the “tissue identity” in the adult organism Tthe presence of these MLL fusion proteins is correlated with the onset of leukemia development (AML, ALL or MLL). MLL-rearranged leukemia is a hard-to-treat disease and the overall survival of these patients is still poor. About 5–10% of all acute leukemia patients carry such MLL-rearrangements.
Specimen Requirements
Collection:
At least 0.5 ml EDTA, citrate (ACD) or Heparinized whole blood or bone marrow aspirates for DNA mutations
Stability:
96hours/4 to 7 days refrigerated
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative or anticoagulant. Specimen received after the stability date. Gross hemolysis. Frozen specimen. Insufficient specimen. Unlabeled. Left un-refrigerated for an extended period.
Storage & Transport
Blood, bone marrow specimens should be kept at room temperature and preferably received within 96 hrs of drawing. Samples that are 4 to 7 days old should be refrigerated.
CPT(s)
81479
New York Approved
NO
TAT
10 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
