CCND1/IGH (t(11;14))
Alternative name:
CCND1(BCL1)/IgH t(11;14)
Methodology
Molecular
Test Description and clinical significance
Genes
CCND1/IGH (t(11;14))
Disease:
Mantle cell lymphoma, multiple myeloma, follicular lymphoma, mature B-cell neoplasm, and endometrial endometrioid adenocarcinoma.
Cyclin D1: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Immunoglobulin Heavy Polypeptide (IGH): Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system
Specimen Requirements
Collection:
FFPE sections, 5-10 sections are recommended at 4 to 10 micron. A minimum of 20 ?l of each DNA with a concentration of at least 5ng/?l and an OD260/280 ratio of 1.7-1.9 and 2.0-2.1 respectively, obtained on a spectrophotometer is required.
Stability:
FFPE blocks- Indefinitely/ FFPE Slides-4 weeks
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative. Insufficient specimen (less than 10% of tumor). Unlabeled or improperly labeled specimens. Decalcified specimens. Improperly stored DNA or RNA.
Storage & Transport
Store FFPE blocks and slides at room temperature. Genomic DNA must be stored at 2–8°C for several weeks post extraction, then at –15 to –25°C for long term storage
CPT(s)
81479 if single gene test or 81168 if translocation analysis
New York Approved
NO
TAT
10 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
