Hereditary Breast and Ovarian Cancer Risk Assessment Panel (Germline)
Alternative name:
NGS–Breast/Ovary Cancer HCP (Hereditary Cancer Panel)
Methodology
Molecular
Test Description and clinical significance
Genes
ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, PTEN, RAD50, RAD51C, RAD51D, STK11, TP53
Disease:
Hereditary breast and ovarian cancer syndrome
This test is used to identify individuals with increased risks for hereditary breast and ovarian cancer syndrome.
Specimen Requirements
Collection:
Specimen should contain least 0.5 mL of blood, Previously extracted DNA is acceptable if stored at appropriate temperature (short term at 2–8 C or long term at -20 C) and should be transported on ice. A minimum of 20 µl of DNA with a concentration of at least 5ng/µl by Qubit using Qubit HS dsDNA assay and an OD260/280 ratio of 1.7-1.9 obtained on a spectrophotometer is required
Stability:
96hours/4 to 7 days refrigerated
Unacceptable Conditions:
Specimen submitted is in the incorrect fixative or anticoagulant. Specimen received after the stability date. Gross hemolysis. Frozen specimen. Insufficient specimen. Unlabeled. Left un-refrigerated for an extended period.
Storage & Transport
Blood specimens should be kept at room temperature and preferably received within 96 hours of drawing. Samples that are 4 to 7 days old should be refrigerated
CPT(s)
81162 (BRCA 1/2), 81408(ATM), 81307(PALB2), 81351(TP53),
81401(MUTYH), 81321(PTEN), 81479x3(CDH1, CHEK2, STK11)
New York Approved
YES
TAT
21 Days
*The CPT codes provided are for informational purposes only and are based on AMA guidelines The billing party is solely responsible for correct CPT coding.
